Panthenol
Panthenol
IUPAC name
2,4-dihydroxy-N-(3-hydroxypropyl)- 3,3-dimethylbutanamide
Other names
Dexpanthenol, Bepanthen
Identifiers
CAS number
PubChem
4678
SMILES
CC(C)(CO)C(C(=O)NCCCO)O
Properties
Molecular formula
C9H19NO4
Molar mass
205.251
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Panthenol is the alcohol analog of pantothenic acid (vitamin B5), and is thus the provitamin of B5. In organisms it is quickly oxidized to pantothenate. Panthenol is a highly viscous transparent liquid at room temperature, but salts of pantothenic acid (for example sodium pantothenate) are powders (typically white). It is well soluble in water, alcohol and propylene glycol, soluble in ether and chloroform, and slightly soluble in glycerin.
Panthenol comes in two enantiomers, D and L. Only D-panthenol (dexpanthenol) is biologically active, however both forms have moisturizing properties. For cosmetic use, panthenol comes either in D form, or as a racemic mixture of D and L (DL-panthenol).
Pantothenol’s expanded chemical formula is: HO-CH2-C(CH3)2-CH(OH)-CONH-CH2CH2CH2-OH.
Uses
In cosmetics, panthenol is a humectant, emollient and moisturizer. It binds to hair follicles readily.
In ointments it is mixed with allantoin, in concentrations of up to 2-5%, and is used for treatment of sunburns, mild burns and minor skin disorders.
Panthenol is not, however, absorbed through the skin and thus has limited effects that are not due to its provitamin character.
If ingested, panthenol is metabolized to pantothenic acid.
Other names for panthenol are:
- Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-
- Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-
- Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-
- D-Panthenol
- Dexpanthenol (DCIR)
- Dexpanthenolum
- Panthenol
- Propanolamine, N-pantoyl-
- d-Pantothenyl alcohol
External links
- PDR Online : Pantothenic Acid
- Sci-toys: ingredients: panthenol
- Household Products Database
- A11HA30
Vitamins (A11)
Fat soluble
A: Retinol - Beta-carotene - Tretinoin - Alpha-carotene
D3: 7-Dehydrocholesterol → Previtamin D3 → Cholecalciferol (D3) → Calcidiol → Calcitriol (active form) → Calcitroic acid
D2: Ergosterol → Ergocalciferol (D2)
D analogues: Dihydrotachysterol - Calcipotriol - Tacalcitol
E: Tocopherol - Tocotrienol
K: Naphthoquinone - Phylloquinone/K1 - Menatetrenone/K2
Water soluble: B vitamins
B1 (Thiamine) - B2 (Riboflavin) - B3 (Niacin, Nicotinamide) - B5 (Pantothenic acid, Dexpanthenol, Pantethine) - B6 (Pyridoxine, Pyridoxal phosphate, Pyridoxamine) - B7 (Biotin) - B9 (Folic acid, Folinic acid) - B12 (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide)
Water soluble: other
C (Ascorbic acid) - Choline
see also enzyme cofactors
Preparations for treatment of wounds and ulcers (D03)
Cicatrizants
Cadexomer iodine - Dextranomer - Dexpanthenol - Calcium pantothenate - Hyaluronic acid - Becaplermin - Glyceryl trinitrate - Isosorbide dinitrate - Crilanomer - Enoxolone
Proteolytic enzymes
Trypsin - Clostridiopeptidase
Retrieved from “http://en.wikipedia.org/wiki/Panthenol”
Categories: B vitamins | Alcohols | Hairdressing | Cosmetic chemicalsHidden categories: All articles with unsourced statements | Articles with unsourced statements since March 2007